Combined Effects of Ambient PM2.5 and Cold Exposure on the Development of Metabolic Disorder

The coexistence of temperature changes and air pollution poses a severe global environmental issue, exacerbating health burdens. aim this study was to clarify the combined effects ambient PM2.5 cold exposure on development metabolic disorders. Male C57BL/6 mice were randomly divided into four groups: TN-FA, TN-PM, TC-FA TC-PM. then exposed concentrated or filtered (FA) under normal (22 °C) (4 environment conditions for 4 weeks. Metabolic-disorder-related indicators, blood pressure, serous lipids, fasting glucose insulin, energy metabolism, mitochondria protein expression in tissues detected comprehensively assessing disorder. results showed that, compared being only, when both (non-optimal), they exhibited more significant disorders regarding tolerance (p < 0.05), insulin resistance lipid adipocytes 0.01) mitochondrial function. This suggested that might substantially exacerbate PM2.5-induced interaction between implied implementing necessary environment-related policies is critical complex challenge.